A Microscope for Automated Live Cell Imaging

The CX-A works with 96 well plates (left) and allows for multiple organelle detection at each acquisition (Source: Nanolive)

Nanolive launched its CX-A today, the first microscope to combine the power of non-invasive, 3D Nanolive imaging with the throughput of automation. “Every new discovery starts with an unprecedented observation. We have created a unique tool to seamlessly follow cells from the macro level of cell populations, down to their individual organelle ecosystem,” says Dr. Sebastien Equis, Nanolive’s co-founder and CTO.

The CX-A, the first labelfree live cell tool for automated live cell imaging (Source: Nanolive

Nanolive’s new product extends the exploration of living cells from single cells to cell populations without compromising on the highest precision and resolution available from Nanolive. It enables scientists to investigate macrocellular dynamics like cell health, proliferation, movement and function as well as micro-organelle dynamics and interactions e.g. mitochondrial network characterization.

The CX-A is designed to work with 96 well plates to multiply and parallelize experimental conditions, hence, bringing significance to each experiment and delivering solid biological insights to researchers.

Furthermore, the system is equipped with multiple imaging modalities to correlate and compare physical and chemical information at each time-point. A fully integrated solution adapted to the most advanced needs. Finally, it delivers 3D data sets for every single image at every single moment.

The CX-A automates data acquisition, thus delivering new insights and understanding into biological processes. Nanolive’s completely redesigned user interface enables first-time users to set-up experiments in just a few minutes and walk away, while the CX-A automatically collects the images. In addition to improving data significance, multiple imaging regimens can be programmed within the same plate allowing users to run different applications in parallel. A real-time preview allows the user to navigate through the data at any time while offering an overview of the experimental protocol. The 3D dataset output can then be exported with just a few clicks to multiple data formats for analysis.

The CX-A enables the user to image living cells over time spans from seconds to weeks (Source: Nanolive)

The device can image living cells for a virtually limitless amount of time. Thanks to its unique harmless way of cell preparation and observation, hundreds of images can be collected each hour, transforming endpoint assays to continuous analysis, for days or weeks, while cells remain unperturbed in a physiologically controlled environment. Users can freely define the perfect imaging regimen for their cells without worrying about phototoxicity or photobleaching. This enables users to continuously monitor their precious, most-sensitive cells and to study their finest behaviors without missing anything. (Source: Nanolive)

Link: CX-A, Nanolive SA, Ecublens, Switzerland

Further reading: Nanolive Launches Live Cell Imaging Tool, photonicsviews.com, 9th December 2015L. Pollaro et al.: Stain‐free 3D Nanoscopy of Living Cells. A new holographic tomographic microscope for quantitative and non‐invasive 3D live cell nanoscopy, Optik Photonik 11(1), February 2016, p. 38-42; DOI: 10.1002/opph.201600008Nanolive Launches Live Cell Imaging Tool, photonicsviews.com, 9th December 2015

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