Scan Makes Eye Diseases Visible at an Early Stage

More and more people over 50 are suffering from age-related vision disorders. According to the World Health Organization, in four out of five cases they could be avoided if they were diagnosed at an early stage. A European team of scientists, including the Leibniz Institute of Photonic Technology IPHT in Jena, has developed a new method that will enable doctors to better detect such eye diseases in the future. The optical method can provide detailed information on the condition of the retinal tissue. With this eye scan, physicians will be able to detect aggressive forms of age-related macular degeneration sooner and even detect neurodegenerative diseases such as Alzheimer’s.

The European research team is building a device on which patients can scan their eyes without contact and receive a diagnosis a few minutes later. (Source: E. Unger, Med. U. Wien)

“We use laser light to obtain comprehensive molecular information about the retina and thus early indications of diseases,“ explains Clara Stiebing from Leibniz IPHT. In order to find out how much laser power the eye can tolerate and which optical pathway the laser takes, the researcher examined retinal samples and designed a structure simulating the conditions in the human eye. Stiebing and the research team from Leibniz IPHT, Friedrich Schiller University Jena, Medical University Vienna, and partners from the Netherlands published their study earlier this month.

The scientists have calculated how intense the laser can be without harming the eye on the basis of applicable safety regulations. The result: a laser beam that is twenty times weaker than the lasers that researchers otherwise use for their spectroscopic measurements. Using label-free, molecularly-sensitive Raman spectroscopy, they are able to obtain a molecular fingerprint of the retina. This reveals how high the content of lipids, proteins, carotenoids and nucleic acids is. In this way, changes in the retina become visible, enabling doctors to detect diseases at an early stage.

A particular challenge for the researchers was that the conditions in the human eye were not optimal for optical measurements. “The fact that we are still able to achieve meaningful, reliable results with the attenuated laser beam clearly shows that our technology will enable us to obtain comprehensive molecular information about the structure of the retina in the future,“ said Clara Stiebing. The partners of the Medical University of Vienna are currently building a device that combines Raman spectroscopy with optical coherence tomography (OCT). With the help of OCT, the morphology of the retina can be very quickly made visible and suspicious areas can be identified. Raman spectroscopy can then be used to characterize these areas at the molecular level. “This enables us to obtain high-resolution images from all layers of the retina including information on their molecular composition,“ explains Jürgen Popp, scientific director of Leibniz IPHT. “The fact that we can now supplement the OCT previously used in ophthalmology with Raman spectroscopy can significantly improve the accuracy of the diagnoses.“

The European research team is currently working on the medical approval of the device. Once approved, the device can be tested on patients. The patients would then sit in front of the device, have their eye scanned without contact and a few minutes later, they would receive a reliable diagnosis.

The new technologies for the diagnosis of age-related eye diseases and neurodegenerative diseases are being researched by scientists at Leibniz IPHT in Jena together with partners from Austria, France and the Netherlands. The European Union is funding the MOON project – multimodal optical diagnostics for age-related diseases of the eye and central nervous system – as part of the Horizon2020 program with around 3.7 million euros as an initiative of the Photonics Public-Private-Partnership Photonics21. The research team plans to be able to carry out initial measurements on patients by the end of the project period at the end of 2020. (Source: L-IPHT)

Reference: C. Stiebing et al.: Nonresonant Raman spectroscopy of isolated human retina samples complying with laser safety regulations for in vivo measurements, Neurophot. 6(4), 041106 (3 September 2019); DOI: 10.1117/1.nph.6.4.041106

Link: MOON – Multimodal Optical Diagnosis of Ocular and Neurodegenerative Disease, Center for Medical Physics and Biomedical Engineering, Christian Doppler Laboratory – OPTRAMED, Medical University of Vienna, Vienna, Austria

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