Laser Light Detects Tumors

It can take up to four weeks before patients can be sure whether the entire tumor has been removed during cancer surgery. A time of agonizing uncer­tainty in which any remaining tumor cells can already multiply again. A team of scientists from Jena has now researched a diagnostic procedure that could revo­lutionize the previous procedure: Using laser light, the researchers make cancerous tissue visible. This enables them to provide the surgical team with real-time information in order to reliably identify tumors and tumor margins and decide how much tissue needs to be cut away.

Multi-contrast image of a tissue affected by skin cancer. Using three different optical-spectroscopic techniques, morphological and molecular aspects become visible, enabling the surgical team to reliably identify cancerous tissue. (Source: Leibniz-IPHT)

This is made possible by a compact micro­scope developed by a research team from the Leibniz Institute of Photonic Techno­logy, Friedrich Schiller Univer­sity, the Univer­sity Hospital and the Fraun­hofer Institute for Applied Optics and Precision Engineering in Jena. It combines three imaging techniques and uses tissue samples to generate spatially high-reso­lution images of the tissue structure during surgery. Software makes patterns and molecular details visible and processes them with the aid of artificial intel­ligence. The automated analysis is faster and promises more reliable results than the currently used frozen section dia­gnostics, which can only be evaluated by an experienced pathologist and still have to be confirmed after­wards.

The optical method, for which the Jena scientists were awarded the renowned Kaiser Friedrich Prize in 2018, helps to prevent weakened patients from having to undergo another operation. It thus makes a significant contribution to improving their chances of recovery. Jürgen Popp, scientific director of Leibniz IPHT, who was also involved in researching the laser rapid test, predicts that the compact micro­scope could be in the clinic in five years’ time.

This could save the German healthcare system considerable costs. “One minute in the operating room is the most expensive minute in the entire clinic,” explains Orlando Guntinas-Lichius, Director of the Department of Oto­laryngo­logy at the University Hospital Jena. In the case of tumors in the head and neck area, for example, cancer cells are found after almost every 10th operation.

And the Jena researchers are already thinking ahead. They are researching a solution that would enable them to use the unique properties of light to detect tumors inside the body at an early stage and remove them imme­diately. “To do this, we need novel methods that no longer work with rigid optics, but with flexible endoscopes,” says Jürgen Popp. Techno­logists at Leibniz IPHT produce such fiber probes: glass fibers that are thinner than a human hair. They open the way to minimally invasive medicine that makes gentle diagnosis and healing possible. “Our vision,” says Jürgen Popp, “is to use light not only to identify the tumor, but to remove it imme­diately. This would eliminate the need for physicians to cut with a scalpel and would enable them to ablate the tumor layer by layer using light in order to remove the tumor from the patient completely”. In ten to fifteen years, the research team hopes to find a solution. Popp predicts that this would “be a giant step towards completely new tumor diag­nostics and therapy”. (Source: IPHT)

Reference: S. Heuke et al.: Multimodal nonlinear microscopy of head and neck carcinoma – toward surgery assisting frozen section analysis, Head & Neck 38, 1545 (2019); DOI: 10.1002/hed.24477

Link: Leibniz Institute of Photonic Technology, Jena, Germany

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